ARIA Workshop

Evolving Targeted Therapies for Cancer

Wednesday, November 2, 2022

Time Event Lead Position
8:00-8:15 am Welcome and Introductory Remarks Susan Hubbard Sandra Davern In Person DJ Nelson Auditorium 1505, 182
8:15-8:55 am Subclonal Hypermutation: A Driver of Therapy Resistance in HER2+/ER+ Breast Cancer Robert Beckman & Rebecca Riggins (Joint Presentation) Virtual DJ Nelson Auditorium 1505, 182
8:55-9:20 am Incorporation of physiologically relevant in-vitro models for cancer research Rebeca San Martin In Person DJ Nelson Auditorium 1505, 182
9:20-9:45 am The Combination of Radiation Therapy and Immunotherapy: Current and Future Perspectives Quaovi Sodji In Person DJ Nelson Auditorium 1505, 182
9:45-10:10 am Poly(Lactic-co-Glycolic Acid) Nanoparticles as Delivery Platforms for Actinium-225 Miguel Toro Gonzalez In Person DJ Nelson Auditorium 1505, 182
10:10-10:25 am Break Break DJ Nelson Auditorium 1505, 182
10:25-10:50 am Cancer Theranostics with (Intrinsically) Radiolabeled Nanomaterials Weibo Cai In Person DJ Nelson Auditorium 1505, 182
10:50-11:15 am Nuclear recoil effect in targeted alpha therapy - do we need to concern about it? Ján Kozempel In Person DJ Nelson Auditorium 1505, 182
11:15-11:40 am Exosome-mediated targeting therapy of breast cancer Yong Jiang Virtual DJ Nelson Auditorium 1505, 182
11:40-12:10 pm Panel Discussion Presenters will lead discussion DJ Nelson Auditorium 1505, 182
12:10-1:10 pm Working Lunch:  Tri-Lab Accelerator Produced Ac-225 Andrew Burgoyne DJ Nelson Auditorium 1505, 182
1:10-1:40 pm Predicting patient specific outcomes via imaging-based mathematical models Thomas Yankeelov Virtual DJ Nelson Auditorium 1505, 182
1:40-2:05 pm Polyazamacrocycle Ligands as Zirconium-89 Chelators: Teaching Old Dogs New Tricks Thaddeus J. Waddas Virtual DJ Nelson Auditorium 1505, 182
2:05-2:30 pm Lead-Specific Chelator Enhances Targeted Alpha-Particle Radiotherapy of [212Pb]VMT-α-NET for SSTR2 Positive Tumors in Mice Dijie Liu Virtual DJ Nelson Auditorium 1505, 182
2:30-2:55 pm Computational modeling of humans for medicine and beyond Ehsan Sami In Person DJ Nelson Auditorium 1505, 182
2:55-3:10 pm Afternoon Break DJ Nelson Auditorium 1505, 182
3:10-3:35 pm A multiscale computational framework for precision dosimetry for radiation therapy Greeshma Agasthya In Person DJ Nelson Auditorium 1505, 182
3:35-4:00 pm Combination of carriers with complementary intratumoral microdistributions of delivered alpha-particles may realize the promise for Actinium-225 in large, solid tumors Stavroula Sofou In Person DJ Nelson Auditorium 1505, 182
4:00-4:25 pm Development and Implementation of Expanded Macrocyclic Chelators for Targeted Radionuclide Therapy Paden King In Person DJ Nelson Auditorium 1505, 182
4:25-5:00 pm Panel Discussion Presenters will lead discussion DJ Nelson Auditorium 1505, 182
5:00-5:15 PM Relocate to 5100 lobby DJ Nelson Auditorium 1505, 182 to building 5100 lobby

Thursday, November 3, 2022

Time Event Profile Location
8:00-8:10 am Introductory Remarks Balendra Sutharshan Sandra Davern In Person DJ Nelson Auditorium 1505, 182
8:10-8:35 am Radiometals in Theranostics: From Chelate Chemistry to in vivo Studies Carolyn J. Anderson Virtual DJ Nelson Auditorium 1505, 182
8:35-9:00 am Leveraging Bioorthogonal Chemistry to Improve Radiopharmaceuticals Brian Zeglis In Person DJ Nelson Auditorium 1505, 182
9:00-9:25 am “Radiobodies”: Nanobodies as molecular constructs for precision medicine Mircea Podar In Person DJ Nelson Auditorium 1505, 182
9:25-9:50 am Monte Carlo simulations for radiation biology and dosimetry in radiopharmaceutical therapy Alejandro Bertolet Reina In Person DJ Nelson Auditorium 1505, 182
9:50-10:15 am Chelation Platform Development for Emerging Medical Radionuclides at Oak Ridge National Laboratory Nikki Thiele In Person DJ Nelson Auditorium 1505, 182
10:15-10:30 am Break DJ Nelson Auditorium 1505, 182
10:30-10:55 am Dose point kernels and their potential application in labeling FAPI-compounds Ashok Tiwari In Person DJ Nelson Auditorium 1505, 182
10:55-11:20 am Metal Chelates & Multimers in Medical Probe Design Johannes Notni Virtual DJ Nelson Auditorium1505, 182
11:20-11:45 am Siderocalin: A Universal Platform for Radiotherapeutics Jennifer Wacker In Person DJ Nelson Auditorium 1505, 182
11:45-12:20 pm Panel Discussion Presenters will lead discussion DJ Nelson Auditorium 1505, 182
12:20-1:20 pm Working Lunch:  The Radioisotope Program at Oak Ridge National Laboratory Roy Copping DJ Nelson Auditorium 1505, 182
1:30-5:00 pm ORNL Tours (optional)
  • High Flux Isotope Reactor
  • Radiochemical Engineering Development Center (Hot Cells)
  • Graphite Reactor
  • Frontier Supercomputer
 ORNL Tour Hosts Different Locations
5:00 pm Adjourn Depart ORNL